role of nicotinic acetylcholine receptors in the regulation of apoptosis
| PAG Title | role of nicotinic acetylcholine receptors in the regulation of apoptosis |
| PAG ID | WAG001238 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | Nicotinic acetylcholine receptors are essential for neuromuscular sigling and are also expressed in non-neurol tissues, where their function is less clear. Although nicotinic acetylcholine receptors are primarily known for their action as ligand-gated ion channels transducing action potentials across sypses, they may have other actions. Nicotinic acetylcholine receptors in neurons alter apoptotic sigling, protecting against cell death in some settings, and this action may in some cases be directed through altertive sigling pathways. In neurons the alpha-7 nicotinic receptor activates PI3 kise through a src-family kise, activating the anti-apoptotic kise AKT (See ¿T sigling pathway?. One pathway involved in AKT sigling involves phosphorylation of the forkhead transcription factor FKHRL1, causing its retention in the cytoplasm associated with 14-3-3, and blocking expression of the apoptotic fas protein. The PI3 kise/AKT pathway protects a broad range of neurons against apoptotic cell death and may block apoptosis triggered by beta-amyloid fragments that contributes to the progression of Alzheimer?disease. If so, nicotinic agents may prove useful in the treatment of this and other neurodegenerative conditions. |
| Species | Homo sapiens |
| nCoCo Score | 763 |
| Base PAG ID | WAG001238 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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